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Thursday, March 23, 2006

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US Finds New H5N1 Subtype

 

As India is trying to deal with the bird flu outbreak in Navapur an Jalgaoan, US scientists revealed that the virus has mutated to a different subtype that can be transmitted to humans. The Center for Disease Control (CDC) presented these findings at the International Conference on Emerging Infectious Disease debunking earlier theory of only one subtype of H5N1. 

The study examined samples from 300 H5N1 infected birds and humans from 2004 till summer 2005 found the second subtype to have mutated from infections in China, Indonesia, Japan, and South Korea. The only cheer is that the second subtype is the result of normal mutation and not re-assortment. Re-assortment is a technical term to describe mutation of a virus when infected with another.

 

However, the news is bad overall. Firstly, it shows that the virus can mutate. Secondly, because of its capacity to mutate, vaccines may not be as efficacious as it would have to deal with more genetic combinations. Thirdly, it shows how much of the virus is still not understood.

While the virus can mutate, it does not mean that an epidemic is imminent, as mammal-to-mammal transmission has not been reported. Balkan nations and Germany have reported cases of cats and dogs (feral and domestic) being infected by birds. India had one unconfirmed case where stray dogs suddenly died when they ate dead poultry dumped in a garbage pit. Although the transmission of the disease from one tiger to another was noticed during the second outbreak in Thailand, it is not clear if the transmission actually happened from the tiger or environmental reasons.

In any event, this is a disease that cannot be easily controlled, contained, or ignored.


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